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Chronic exposure of the lungs to cigarette smoke disrupts the mitochondrial activity and endoplasmic reticulum (ER) homeostasis that triggers an unresolvable unfolded protein response activation

Figure 1 is a forest plot of the 3-4-fold increases in risk estimates of lung cancer for cigarette smokers who also reported using electronic cigarettes (vaping) compared to those smokers who did not vape

Among these, regular cigarettes hold a dominant market share, as they cater to a broad spectrum of smokers who prefer traditional cigarette options

Even one puff will cause your blood vessels to shrink

But its up to the FDA to decide whether the potential benefits of IQOS outweigh its potential harms